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It works by killing sensitive bacteria in the urinary tract by stopping the production of essential proteins needed by the bacteria to survive.</p> <p>Do NOT use NegGram if:</p> you are allergic to any ingredient in NegGram you have the blood disease porphyria or a history of convulsions you are undergoing cancer chemotherapy with the medicine melphalan or related medicines, or you are taking an antiarrhythmic for abnormal heartbeat (eg, quinidine, procainamide, amiodarone, sotalol) <p>Contact your doctor or health care provider right away if any of these apply to you.</p> <p>Before using NegGram :</p> <p>Some medical conditions may interact with NegGram . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:</p> if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have Alzheimer disease, a central nervous system disease, hardening of the arteries in your brain, increased pressure in your brain, liver problems, sensitivity to the sun, severe kidney problems, or a family history of heartbeat problems <p>Some MEDICINES MAY INTERACT with NegGram . Tell your health care provider if you are taking any other medicines, especially any of the following:</p> Anticoagulants (eg, warfarin), antiarrhythmics (eg, quinidine, procainamide, amiodarone, sotalol), certain medicines that affect heartbeat (eg, cisapride, erythromycin, amitriptyline), cyclosporine, melphalan, or theophylline because the risk of their side effects may be increased by NegGram Probenecid because the effectiveness of NegGram may be decreased and the risk of its side effects may be increased by NegGram <p>This may not be a complete list of all interactions that may occur. Ask your health care provider if NegGram may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.</p> <p>How to use NegGram :</p> <p>Use NegGram as directed by your doctor. Check the label on the medicine for exact dosing instructions.</p> <p>Take NegGram with or without food. If stomach upset occurs, take with food to reduce stomach irritation.</p> <p>Do not take products containing magnesium (eg, quinapril, didanosine, vitamins), aluminum, calcium, sucralfate, iron, or zinc preparations within 2 to 3 hours of taking NegGram . These products bind with the medicine preventing its absorption.</p> <p>Drink a full glass of water with each dose. Drink several additional glasses of water daily unless otherwise directed by your doctor. Do not drink products with caffeine while taking NegGram .</p> <p>To clear up your infection completely, take NegGram for the full course of treatment. Keep taking it even if you feel better in a few days.</p> <p>If you miss a dose of NegGram , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.</p> <p>Ask your health care provider any questions you may have about how to use NegGram .</p> <p>Important safety information:</p> <p>NegGram can cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use NegGram with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.</p> <p>NegGram may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to NegGram . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.</p> <p>Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.</p> <p>NegGram only works against bacteria; it does not treat viral infections (eg, the common cold).</p> <p>Be sure to use NegGram for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.</p> <p>Long-term or repeated use of NegGram may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.</p> <p>Diabetes patients - NegGram may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.</p> <p>Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use NegGram . 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